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UA Life Science Research - BioGate
Katerina Dvorak
Research Associate Professor
Contact Information
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Address: 1501 N Campbell LSN #625 PO Box 245044
Tucson, AZ 85724
Phone: (520) 626-3934
E-Mail: kdvorak@email.arizona.edu
Degrees
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Ph.D., University of Arizona 2000
M.S., University of Arizona 1998
Department Affiliations
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Cell Biology & Anatomy, Arizona Cancer Center
Program Affiliations
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Cell Biology & Anatomy, Cancer Biology GIDP
Research Areas
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Cancer Biology, Cell Biology, Toxicology, Pathogenesis, Nutrition, Clinical Research, Immunology
Research Interests
My major research interest is focused on the role of bile acids and gastric acids in the development of Barrett's esophagus and esophageal adenocarcinoma. We study signaling pathways induced by bile acids and gastric acids in esophageal cell lines as well as in human biopsies with major focus on anti-apoptotic signaling pathways, such as JAK-STAT and NF-kB pathways.
Selected Publications
Bernstein C, Bernstein H, Payne CM, Dvorak K, Garewal H. Feb 2008. Field defects in progression to gastrointestinal tract cancers. Cancer Lett, 260:1-10
Dvorak K Chavarria M Payne CM Ramsey L Crowley-Weber C Dvorakova B Dvorak B Bernstein H Holubec H Sampliner RE Bernstein C Prasad A Green SB Garewal H. Sep 2007. Activation of the Interleukin-6/STAT3 Antiapoptotic Pathway in Esophageal Cells by Bile Acids and Low pH: Relevance to Barrett's Esophagus. Clin Cancer Res, 13:5305-5313
Bernstein H Holubec H Bernstein C Ignatenko NA Gerner E Dvorak K Besselsen D Blohm-Mangone KA Padilla-Torres J Dvorakova B Garewal H Payne CM. Mar 2007. Deoxycholate-induced colitis is markedly attenuated in Nos2 knockout mice in association with modulation of gene expression profiles. Dig Dis Sci, 52:628-42
Guy NC, Garewal H, Holubec H, Bernstein H, Payne CM, Bernstein C, Bhattacharyya AK, Dvorak K. Dec 2006. A novel dietary-related model of esophagitis and Barrett's esophagus, a premalignant lesion. Nutr Cancer, 59:217-27
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