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Address: Life Sciences North 442
PO Box 245044
Tucson, AZ 85724
Phone: (520) 626-2553
E-Mail: stjohn@u.arizona.edu

Faculty Homepage

Research Interests

Binding and uptake of amyloid-β peptide in CNS neurons. Amyloid-β-induced changes in the function and survival of CNS neurons. Dynamic movements of neurotransmitter receptors in neurons and muscle cells. Self-assembly of amyloid-β peptides. Effects of amyloid-β on the trafficking of AMPA-type glutamate receptors in chemical LTD – an in vitro model of synaptic defects in Alzheimer's disease. Alzheimer's disease.

Selected Publications

Yue X, Tumati S, Navratilova E, Stropova D, St John PA Vanderah TW, Roeske WR, Yamamura HI, Varga EV. Apr 2008. Sustained morphine treatment augments basal CGRP release from cultured primary sensory neurons in a Raf-1 dependent manner. Eur J Pharmacol, 584:272-7

Wu J Hu J Chen YP Takeo T Suga S Dechon J Liu Q Yang KC St John PA Hu G Wang H Wakui M. Oct 2006. Iptakalim modulates ATP-sensitive K(+) channels in dopamine neurons from rat substantia nigra pars compacta. J Pharmacol Exp Ther, 319:155-64

Wu J Liu Q Yu K Hu J Kuo YP Segerberg M St John PA Lukas RJ. Oct 2006. Roles of nicotinic acetylcholine receptor beta subunits in function of human alpha4-containing nicotinic receptors. J Physiol, 576:103-18