In the news / Aging

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Dr. Roberta Brinton, director of the Center for Innovation in Brain Science, received a $15.1 million grant from the National Institutes on Aging to investigate perimenopausal brain aging.
 
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Nearly one quarter of the global disease burden is attributed to the elderly - a group expected to more than double by 2050. 

 
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A University of Arizona research team led by Roberta Diaz Brinton, director of the UArizona Health Sciences Center for Innovation in Brain Science and a member of the BIO5 Institute, have developed a new therapy for Alzheimer’s disease designed to restore cognitive function in early-stage patients. The therapy is now proceeding through a Phase 2b clinical trial.
 
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Sleep plays many important roles in health maintenance and disease prevention. Adding a focus on sleep may improve your daytime function and quality of life. In addition to heart health, sleep is closely linked with mood, ability to handle stress, risk for depression, and many brain functions.
 
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Despite slowdowns in research suffered by universities around the world due to the pandemic, the University of Arizona has experienced solid growth in the commercialization of university inventions. In the last fiscal year alone UArizona received 274 invention disclosures and launched 17 startups.
 
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Despite slowdowns in research suffered by universities around the world due to the pandemic, the University of Arizona has experienced solid growth in the commercialization of university inventions.
 
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Some people who develop skin cancer don't have pale skin or red hair. The University of Arizona Skin Cancer Institute's Dr. Clara Curiel is identifying specific biomarkers that can identify those who don't typically fall within high-risk groups.
 
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Hormone therapy is the most effective treatment for the symptoms of menopause, which can include hot flashes, night sweats, insomnia, weight gain, and depression. During the study, Dr. Roberta Brinton led a team to examine the effects of individual U.S. Food and Drug Administration-approved hormone therapy medications, including estrogens and progestins, and combination therapies on neurodegenerative disease and found that using natural steroids estradiol or progesterone resulted in greater risk reduction than the use of synthetic hormones.
 
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Dr. Fei Yin, of the Center for Innovation in Brain Science, the institute headed by Dr. Roberta Brinton, has received a $1.1 million grant from the National Institutes of Health to determine the role of an Alzheimer’s risk-factor gene in regulating the brain energy production system.
 
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There is a new treatment for Alzheimer's, after 20 years, now approved by the FDA, a drug called Aducanumab. This drug targets beta-amyloid plaques in the brain and removes some of those plaques.
 
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The mentoring relationship between two University of Arizona faculty members is advancing research for patients with brain damage at any stage in life. One of those research leaders, Dr. Roberta Brinton, founding director of the UArizona Center for Innovation in Brain Science and BIO5 member, has discovered that regenerative therapeutics may help pediatric and aging populations. This research out of UArizona Health Sciences may help both premature babies and patients with Alzheimer’s disease.
 
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Dr. Roberta Brinton, the director of the Center for Innovation in Brain Science at the University of Arizona and BIO5 member discovered the disparities in how women are more likely to develop brain diseases and autoimmune conditions such as Alzheimer's and Multiple Sclerosis.
 
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Dr. Joanna Masel professor of ecology and evolutionary biology at the University of Arizona and BIO5 member uses mathematical models to better understand evolutionary consequences in biochemistry, genetics, cellular biology, physiology, and ecology.

 
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By 2034, U.S. Census data show that the number of Americans age 65 and older will for the first time outnumber those under 18. By 2050, there will be an estimated 2.1 billion people in the world age 65 and older.
 
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Emily Merritt, who is pursuing a doctorate in immunobiology, was one of the first students to participate in the Infection and Inflammation as Drivers of Aging, a program funded by a National Institutes of Health T32 training grant, which supports four graduate or post-doctoral students annually. She and four other students presented their research virtually at the inaugural Infection and Inflammation as Drivers of Aging symposium in January. The research topics ranged from chronic inflammatory response to ischemic stroke and tracking antibody responses to SARS-CoV-2, the virus that causes COVID-19, in aging individuals. Merritt presented on Toxoplasma gondii, a single-celled parasite she studies under the guidance of Dr. Anita Koshy, professor of neurology and BIO5 member.
 
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Recognizing progress BIO5 researchers are making against this devastating neurodegenerative condition during Parkinson’s Disease Awareness Month.
 
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We’re highlighting our researchers’ efforts against this major cause of death and disability in the United States during National Traumatic Brain Injury Month.
 
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During National Endometriosis Awareness Month, we’re highlighting our researchers’ efforts to tackle this common women’s health problem.