Dominic V Mcgrath
Publications
Design, synthesis, characterization, and photodynamic activity of mitochondria specific asymmetric ZnPc–Rh B conjugates are described. Conjugation of asymmetric ZnPc–OH chromophores 3a and 3b with rhodamine B via the corresponding DIC-activated ester gave the desired near IR-absorbing asymmetric ZnPc–Rh B conjugates 1a and 1b. Conjugates 1a and 1b were shown to produce singlet oxygen upon illumination in DMSO, MeOH and THF. Fluorescence aggregation studies of the dyes 1a, 1b, 3a and 3b in DMSO and phosphate buffered saline (PBS) solution showed that conjugates 1a and 1b were less aggregated compared to the corresponding non-conjugates 3a and 3b suggesting that incorporation of Rh B lowered aggregation of the conjugates in the PBS solution. The four dyes studied have log D7.4 values between 2.31 and 2.48, with the sulfur-containing conjugate 1b being the most hydrophobic. All the dyes showed negligible dark toxicity when colon 26 cells were treated with 5 μM of the dyes while 10–15% cell death was observed for dye concentrations of 15 μM. Illumination (700 ± 40 nm, 45 J/cm2, 15 min) of the cells ([dye] = 15 μM) gave 70% cell death for ZnPc–Rh B conjugates 1a and 1b while no killing for non-conjugates 3a and 3b suggesting that the incorporation of the Rh B in the photosensitizer lowered the aggregation and subsequently improved cellular uptake and phototoxicity.
Abstract:
Monolayer films were fabricated from photochromic monodendrons with amphiphilic character. Amphiphilicity was established by a hydrophilic focal point (crown-ether) and hydrophilic tails (alkyl chains) that flank a photochromic azobenzene moiety. The monolayer forming properties of four generations of dendrons along with both stearic acid and a reference azobenzene compound with a carboxylic acid focal point group were determined.
Abstract:
Azobenzene-containing amphiphilic dendrimer was used to fabricate a photosensitive monolayer. A crown-ether moiety served as a polar head and a polyether fragment with long-chain alkyl tails providing hydrophobicity for an overall amphiphilic character. The architecture exhibited two dissimilar bulky terminal fragments.
Abstract:
The polarity of the open form of spiropyrans is suitable for use as surfactants and for controlling the hydrophilicity of the dendrimer surface with the use of light. Spiropyrans as a peripheral unit of dendrimer with a non-polar inner core will lead to the formation of macromolecules with photolytically-controlled amphiphilic character. In this connection, spiropyran subunits were introduced on the surface of dendrimers prepared using the convergent synthetic strategy to modify the dendrimers' properties.
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