John JB Allen

John JB Allen

Professor, Psychology
Distinguished Professor
Professor, BIO5 Institute
Member of the General Faculty
Professor, Neuroscience - GIDP
Member of the General Faculty
Member of the Graduate Faculty
Primary Department
Department Affiliations
Contact
(520) 621-7448

Work Summary

Depression is a major health problem that is often chronic or recurrent. Existing treatments have limited effectiveness, and are provided wihtout a clear indication that they will match a particular patient's needs. In this era of precision medicine, we strive to develop neurally-informed treatments for depression and related disorders.

Research Interest

Dr. Allen’s research spans several areas, but the main focus is the etiology and treatment of mood and anxiety disorders. His work focuses on identifying risk factors for depression using electroencephalographic and autonomic psychophysiological measures, especially EEG asymmetry, resting state fMRI connectivity, and cardiac vagal control. Based on these findings, he is developing novel and neurally-informed treatments for mood and anxiety disorders, including Transcranial Ultrasound, EEG biofeedback, and Transcranial Direct Current and Transcranial Alternating Current stimulation. Other work includes understanding how emotion and emotional disorders influence the way we make decisions and monitor our actions. Keywords: Depression, Neuromodulation, EEG, Resting-state fMRI

Publications

Bourassa, K. J., Allen, J. J., Mehl, M. R., & Sbarra, D. A. (2017). Impact of Narrative Expressive Writing on Heart Rate, Heart Rate Variability, and Blood Pressure After Marital Separation. Psychosomatic medicine, 79(6), 697--705.
J., J., & Dveirin, K. (2003). Mechanism of wart disappearance: An alternative hypothesis. Archives of Pediatrics and Adolescent Medicine, 157(5), 490-.
Allen, J. J., Chapman, L. J., Chapman, J. P., Vuchetich, J. P., & Frost, L. A. (1987). Prediction of Psychoticlike Symptoms in Hypothetically Psychosis-Prone College Students. Journal of Abnormal Psychology, 96(2), 83-88.

PMID: 3584670;Abstract:

Correlates of psychotic and psychoticlike symptoms were examined in 60 college students who scored deviantly high on the Perceptual Aberration Scale. High scorers on this scale who also scored high on both the Impulsive Nonconformity Scale and the Depression subscale of the General Behavior Inventory (GBI) showed the most deviant psychotic and psychoticlike symptoms. Moreover, performance on a task of referential communication, the Password Task, was significantly related to such symptoms. The Perceptual Aberration Scale, the Impulsive Nonconformity Scale, and the GBI Depression subscale are recommended for concurrent use in mass screening to select individuals likely to exhibit psychotic or psychoticlike symptoms. © 1987 American Psychological Association, Inc.

Lane, R. D., Weidenbacher, H., Smith, R., Fort, C., Thayer, J. F., & Allen, J. J. (2013). Subgenual anterior cingulate cortex activity covariation with cardiac vagal control is altered in depression. Journal of Affective Disorders, 150(2), 565-570.

PMID: 23473547;Abstract:

Background: We tested the hypothesis that subgenual anterior cingulate cortex (sgACC) participates in concurrently regulating shifts in both affective state and cardiac vagal control. Methods: Eleven healthy adults and 8 depressed subjects performed the Emotional Counting Stroop task in alternating 15-second blocks of emotion words and neutral words while undergoing functional magnetic resonance imaging (fMRI) and electrocardiography (ECG). We measured the absolute value of change between adjacent 15-second blocks in both cardiac vagal control and the BOLD signal in specific regions of interest. Results: Strong positive correlations were observed in healthy control participants between changes in cardiac vagal control and changes in BOLD signal intensity in sgACC (BA25) (right: r=.67, p.02; left r=.69, p.02), as well as other key structures in the medial visceromotor network. Depressed subjects showed no significant correlations between cardiac vagal control and BOLD signal intensity within BA25 or any other brain region examined. During the transition from depression-specific emotion blocks to neutral blocks, the correlation between BOLD signal change in BA25 and cardiac vagal control change was significantly greater in controls than in depressed subjects (p.04). Conclusions: Findings in healthy volunteers suggest that sgACC participates in affective state shifting. The latter function appears to be altered in depressed individuals, and may have implications for the unvarying mood and vagal dysfunction associated with depression. Limitations: Limitations include a small sample size, an inability to disentangle afferent versus efferent contributions to the results, and the lack of a whole-brain analysis. © 2013 Elsevier B.V.

J., J., Law, H., & Laravuso, J. J. (1996). Items for assessing posthypnotic recognition amnesia with the HGSHS:A and the SHSS:C. International Journal of Clinical and Experimental Hypnosis, 44(1), 52-65.

PMID: 8582778;Abstract:

A procedure for assessing posthypnotic recognition amnesia is described. A set of items for the Harvard Group Scale of Hypnotic Susceptibility, Form A and for the Stanford Hypnotic Susceptibility Scale, Form C were developed and analyzed for reliability and their ability to discriminate individuals who demonstrate posthypnotic amnesia. Recognition amnesia could be assessed as reliably as recall amnesia, and posthypnotic recognition amnesia identified a select subgroup of high hypnotizable individuals who had higher scores on the screening scales. These items may prove useful for assessing posthypnotic recognition amnesia in conjunction with widely used scales of hypnotic susceptibility.